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Dear Healthcare Professional Letter

Tivicay (dolutegravir): updated information on neural tube defects reported in Tsepamo Study, Botswana
Tecentriq (atezolizumab), identified risk of severe cutaneous adverse reactions (SCARs) direct healthcare professional communication (DHPC)
Cellcept (mycophenolate mopetil)
Retinoids (Isotretinoin) - update on teratogenicity and neuropsychiatric disorders Direct Healthcare
Important information about Mabthera
Important information on Dacarbazine medac 200 mg: decreased stability after reconstitution
Leuprorelin-containing depot products: need to strictly follow instructions for reconstitution and administration to reduce the risk of handling errors that may result in lack of efficacy
5-Fluorouracil (i.v.), capecitabine and tegafur containing products
The risk of birth defects from the recently published epidemiological studies for Zofran (Ondansetron)
New important information on safety of medicine Esmya, 5 mg tablets

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